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. 2015 Jul 14;5(7):e007231. doi: 10.1136/bmjopen-2014-007231

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Stage I: Short-term evaluation of 0.75–3.0 mg/day alprazolam on biochemical variables related to chronic stress. Stage II: Short-term evaluation of 0.75–3.0 mg/day alprazolam on cognitive and clinical variables related to chronic stress. Stage III: Intermediate-term evaluation of low alprazolam doses in cognitive, clinical and quality of life indicators (GEMA, Gador study of Estres Modulation by Alprazolam).