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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1994 Nov 8;91(23):10908–10912. doi: 10.1073/pnas.91.23.10908

Rabies ribonucleocapsid as an oral immunogen and immunological enhancer.

D C Hooper 1, I Pierard 1, A Modelska 1, L Otvos Jr 1, Z F Fu 1, H Koprowski 1, B Dietzschold 1
PMCID: PMC45135  PMID: 7971982

Abstract

The administration of rabies ribonucleocapsid (RNP) by oral as well as parenteral routes was found to prime specific T cells and elicit N-protein-specific antibodies. per os and intramuscular immunization led to the production of antibodies of the IgA and IgG isotypes, respectively. Mice primed orally with RNP produced significantly enhanced amounts of virus-neutralizing antibody, compared with non-immune controls, upon subsequent parenteral booster immunization with inactivated rabies virus. Thus oral immunization with rabies RNP primed cells capable of mediating a secondary systemic response to rabies virus. The results of experiments in which peptide and protein antigens were administered either physically coupled to or mixed with RNP indicate that RNP has an inherent capacity to enhance immune responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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