Fig. 5.

TsSP interacts with the MR on human monocytes. The effect of blocking antibodies for the mannose receptor (MR, CD206) or its isotype control (both 10 μg/ml) on (a) the TsSP-induced patrolling phenotype or (b) transendothelial migration capacity was tested and subsequently quantified. Experiments were performed in triplicate using cells derived from 8 (a) or 5 (b) different human donors and the results are presented as the mean +/− SEM. ** or ^## p < 0.01, ***p < 0.001 as determined by ANOVA and Students t test