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. 2015 Jul 25;15:545. doi: 10.1186/s12885-015-1544-y

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© Timmermans-Sprang et al. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — IC50 curves. CMT-U27 (high TOP/FOP ratio, >30) and CIPm cells (low TOP/FOP ratio, <2) were grown for 40 h with the three inhibitors, BEZ235 (a), Everolimus (b) and Src-l1 (c) in increasing concentrations (BEZ235 0.1nM–100 uM, Everolimus 0.01 nM–10 μM and Src-I1 0.1 μM–20 μM). After 40 h the cell viability was measured with a MTT assay. Results, expressed as % of control, are the mean (±SEM) of three independent experiments. *P < 0.01 versus appropriate cell line control (DMSO). IC50 values were calculated with Sigma-Plot software (version 12.5)