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Two FALS families with the SOD1 H46R mutations. a Family trees of Family 1 and 2. All of the patients showed the same uniform feature that initial symptoms were restricted to the flexor muscle group in the unilateral distal leg. b Short-T1 inversion recovery MR images revealed high intensity lesions in the gastrocnemial and soleus muscles of the patient 2, 3, 4, and 5. Brain MRI of patient 1 showed frontal lobe-dominant atrophy
