Table 2.
Primary outcomes: daily knee pain severity measured with a diary and knee pain and function measured with the Knee Injury and Osteoarthritis Outcome Score
| Paracetamol (n= 52) Mean (SD) | Diclofenac (n= 52) Mean (SD) | Mean differencesa (95% CI) | Effect size | |
|---|---|---|---|---|
| Course of daily knee pain during: | ||||
| 2 weeks | 3.5 (2.1) | 3.0 (2.1) | 0.5 (−0.2 to 1.3) | 0.35 |
| 4 weeks | 3.3 (2.1) | 3.5 (2.1) | −0.2 (−1.0 to 0.7) | −0.03 |
|
| ||||
| KOOS painb | ||||
| 3 weeks | 38.3 (19.5) | 39.6 (20.7) | −1.6 (−9.5 to 6.3) | 0.04 |
| 6 weeks | 35.0 (19.4) | 40.2 (22.1) | −5.6 (−13.7 to 2.5) | −0.16 |
| 9 weeks | 34.8 (18.8) | 38.5 (20.7) | −3.5 (−11.3 to 4.4) | −0.03 |
| 12 weeks | 34.8 (19.4) | 37.4 (21.0) | −2.8 (−10.7 to 5.1) | 0.01 |
|
| ||||
| KOOS functionb | ||||
| 3 weeks | 33.9 (19.3) | 34.2 (21.7) | −0.6 (−8.7 to 7.6) | 0.07 |
| 6 weeks | 31.9 (19.9) | 33.1 (20.6) | −1.8 (−9.7 to 6.2) | 0.04 |
| 9 weeks | 28.3 (19.7) | 33.1 (20.3) | −4.6 (−12.6 to 3.3) | −0.10 |
| 12 weeks | 28.4 (19.5) | 31.4 (20.2) | −2.7 (−10.6 to 5.0) | −0.02 |
a
Results of the generalised estimating equations analyses.
b
A higher score is more pain/worse function.
KOOS= Knee Injury and Osteoarthritis Outcome Score.