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. 2015 Apr 16;43(13):6373–6383. doi: 10.1093/nar/gkv302

Figure 1.

Figure 1.

The 3′ overhang of the typical telomeres of Streptomyces. Shown are the first 91 nt that span the first four palindromes (Roman numerals). The last nt (16, 35, 65 and 89) of four templates used in this study are indicated. Palindromes II to IV are folded into hairpins. The G:A sheared pairings are boxed. The Tap binding sequences in Palindromes II and III are marked in blue. Palindrome I is duplexed with the 13-nt oligonucleotide primer (in red) synthesized from the Tpg primer (yellow disk). For an approximate mechanistic perspective of the molecular interactions, the two proteins are assumed to be globular and drawn to scale based on the diameters (Tpg: 39.3 Å; or 11.5 bp; Tap: 62.4 Å or 18.4 bp) estimated from their amino acid contents. Tap is placed over its binding sequence at Palindrome II, and bound to Tpg (9), which, in turn, is covalently linked to the first nucleotide C of the primer through a phosphodiester bond (dash line) at the Thr-114 (red shaded ‘T’).