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. 2015 Jun 1;43(13):6270–6284. doi: 10.1093/nar/gkv574

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — A working model for PRC2 regulation of Pol III transcription. (A) A model depicting the role of c-Myc regulation of Pol III transcription through recruiting acetyltransferase TRRAP and GCN5, consisting one of the mechanisms accounting for activation of Pol III transcription (17,18). (B) A proposed model based on findings in the present investigation that PRC2 component EZH2 interacts with TFIIIC complex and is recruited to the promoter of target non-translated RNA genes. EZH2 then trimethylates H3K27 and forms a suppressive complex and represses target non-translated RNA transcription.