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TLP-dependent promoter selection model of TFIIA. TLP inhibits Taspase1-mediated maturation of TFIIAαβ and represses TATA gene expression. TLP forms a complex with both the processed and unprocessed forms of TFIIAαβ and potentiates TLP-mediated genes. Consequently, TLP governs promoter selectivity of TFIIA and regulates gene expression.
