Table 2.
Brain volumes and cognitive test results in the full sample and stratified by eGFR and UACR
| Parameter | All |
eGFR ≥ 90 mL/min/1.73 m2 (n = 287) |
eGFR 60–89 mL/min/1.73 m2 (n = 145) |
eGFR 45–59 mL/min/1.73 m2 (n = 46) |
P-value | UACR <10 mg/g (n = 246) |
UACR 10–29 mg/g (n = 140) |
UACR 30–300 mg/g (n = 92) |
P-value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |||
| MRI volumea | ||||||||||||||||
| TICV | 1339.9 | 142.5 | 1334.5 | 142.6 | 1357.3 | 139.0 | 1318.4 | 151.3 | 0.06 | 1338.1 | 141.6 | 1348.4 | 152.0 | 1330.8 | 129.1 | 0.87 |
| CSFVb | 254.2 | 44.8 | 245.7 | 40.4 | 267.5 | 46.3 | 268.3 | 54.3 | 1.5 × 10−7 | 252.9 | 42.9 | 254.8 | 48.5 | 257.0 | 43.9 | 0.12 |
| TWMVb | 575.2 | 72.6 | 573.7 | 74.0 | 582.0 | 70.1 | 562.7 | 71.3 | 0.78 | 574.6 | 72.2 | 580.5 | 77.7 | 568.1 | 64.8 | 0.58 |
| TGMVb | 510.2 | 52.0 | 514.9 | 51.1 | 507.8 | 51.6 | 485.6 | 52.9 | 1.5 × 10−7 | 510.3 | 54.1 | 512.5 | 51.4 | 505.7 | 46.6 | 0.27 |
| TWMLVb,c | 4.3 | 6.7 | 3.2 | 5.2 | 5.4 | 8.4 | 7.2 | 8.0 | 0.0004 | 4.2 | 7.1 | 4.0 | 6.3 | 4.8 | 6.5 | 0.12 |
| HWMV | 3.4 | 0.3 | 3.4 | 0.3 | 3.4 | 0.3 | 3.3 | 0.4 | 0.16 | 3.4 | 0.3 | 3.4 | 0.3 | 3.3 | 0.3 | 0.68 |
| HGMV | 8.6 | 1.1 | 8.8 | 1.1 | 8.4 | 1.0 | 8.1 | 1.0 | 0.0001 | 8.6 | 1.1 | 8.7 | 1.1 | 8.6 | 1.1 | 0.51 |
| Cognitive test | ||||||||||||||||
| RAVLT | 41.6 | 10.2 | 43.3 | 10.0 | 39.5 | 10.1 | 38.1 | 10.0 | 0.00008 | 42.0 | 10.4 | 41.9 | 9.7 | 40.2 | 10.5 | 0.19 |
| Rey total_long | 7.4 | 3.6 | 7.9 | 3.5 | 6.6 | 3.5 | 6.2 | 3.5 | 0.0001 | 7.5 | 3.6 | 7.3 | 3.6 | 7.0 | 3.5 | 0.47 |
| 3MSE | 90.6 | 7.1 | 91.7 | 6.8 | 89.6 | 6.7 | 86.9 | 8.5 | 0.0002 | 90.8 | 7.2 | 90.5 | 8.1 | 90.2 | 7.1 | 0.75 |
| Stroopc | 35.5 | 19.9 | 31.8 | 15.8 | 39.4 | 20.1 | 46.2 | 32.8 | 0.0008 | 34.0 | 18.1 | 35.1 | 18.3 | 39.9 | 25.5 | 0.12 |
| Semantic Fluency | 15.9 | 4.4 | 16.4 | 4.5 | 15.3 | 4.1 | 14.1 | 4.5 | 0.0005 | 16.1 | 4.9 | 15.7 | 4.0 | 15.5 | 3.8 | 0.26 |
| DSST | 47.8 | 15.3 | 50.5 | 16.1 | 44.8 | 13.4 | 40.6 | 12.0 | 3.6 × 10−6 | 48.8 | 15.1 | 46.7 | 14.8 | 46.8 | 16.5 | 0.16 |
eGFR, estimated glomerular filtration rate; UACR, urine albumin:creatinine ratio; SD, standard deviation; TICV, total intracranial volume; CSFV, cerebrospinal fluid volume; TWMV, total white matter volume; TGMV, total gray matter volume; TWMLV, total white matter lesion volume; HGMV, hippocampus gray matter volume; HWMV, hippocampus white matter volume; RAVLT, Rey Auditory Verbal Learning Test; 3MSE, Modified Mini-Mental State Examination; DSST, Digit Symbol Substitution Test.
aMRI volumes expressed in milliliters.
bAdjusted for TICV when calculating P-value using GEE model.
cLog transformed for calculating P-value.