Table 1.
Baseline characteristics of study participants by gender
| Males (n = 669) | Females (n = 425) | All (n = 1094) | |
|---|---|---|---|
| Mean age, years | 54.2 ± 10.8 | 55.2 ± 10.5 | 54.6 ± 10.7 |
| Current smoker | 201 (30%) | 120 (28%) | 321 (29%) |
| Mean blood pressure, mmHg | |||
| Systolic | 150 ± 24 | 150 ± 24 | 150 ± 24 |
| Diastolic | 96 ± 15 | 94 ± 13 | 96 ± 14 |
| Mean arterial blood pressure, mmHg | 114 ± 16 | 113 ± 15 | 114 ± 16 |
| Mean body mass index, kg/m2 | 30.1 ± 6.2 | 31.3 ± 7.1 | 30.6 ± 6.6 |
| Mean hematocrit, % | 41.1 ± 4.6 | 36.8 ± 4.1 | 39.4 ± 4.9 |
| Median eGFR, mL/min/1.73 m2 | 49 (38–59) | 45 (34–56) | 48 (36–58) |
| eGFR category, mL/min/1.73 m2 | |||
| ≥60 | 159 (24%) | 63 (15%) | 222 (20%) |
| 45–59 | 254 (38%) | 155 (36%) | 409 (37%) |
| 30–44 | 178 (26%) | 135 (32%) | 313 (29%) |
| <30 | 78 (12%) | 72 (17%) | 150 (14%) |
| Mean serum albumin, g/dL | 4.3 ± 0.3 | 4.2 ± 0.3 | 4.2 ± 0.3 |
| Mean C-reactive protein, mg/dL | 0.7 ± 1.0 | 0.9 ± 1.0 | 0.8 ± 1.0 |
| Median urine protein-to-creatinine ratio | 0.08 (0.03–0.36) | 0.08 (0.04–0.37) | 0.08 (0.03–0.36) |
| Proteinuria >0.22 | 228 (34%) | 129 (30%) | 357 (33%) |
| Randomized blood pressure goal, mmHg | |||
| ≤92 | 334 (50%) | 206 (48%) | 540 (49%) |
| 102–107 | 335 (50%) | 219 (52%) | 554 (51%) |
| Randomized study drug | |||
| Ramipril | 267 (40%) | 169 (40%) | 436 (40%) |
| Metoprolol | 271 (40%) | 170 (40%) | 441 (40%) |
| Amlodipine | 131 (20%) | 86 (20%) | 217 (20%) |
Values presented as mean ± SD, median (IQR), or n (%).
eGFR, estimated glomerular filtration rate.