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Plasma glucose following fasting for 6 hours. Dog W was treated by readministration of AAV-G6Pase, pseudotyped as AAV8, in response to life-threatening hypoglycemia, anorexia, and pancreatitis at 15 months of age. Initial treatment with AAV-G6Pase was as a neonate with AAV9 (Demaster, Luo et al. 2012).
