Table 7.
Impact of vernolide and vernodalol on the development of early sporogonic stages in vitro
| Test compounds | Experimenta | Mean ESS counts (95% CI)b | Percentage inhibition of ESS (95% CI) |
|---|---|---|---|
| Vernodalol | 1 | 24 (21–26) | 79.3 (77.3–81.4) |
| 2 | 12 (8–16) | 89.7 (86.4–92.9) | |
| 3 | 92 (77–107) | 69.3 (64.3–74.3) | |
| Vernolide | 1 | 103 (90–115) | 9.4 (0–20.5) |
| 2 | 79 (63–95) | 30.6 (16.7–44.5) | |
| 3 | 201 (182–220) | 33 (26.6–39.3) | |
| Solvent control (0.2% DMSO) | 1 | 113 (93–134) | |
| 2 | 114 (97–132) | ||
| 3 | 300 (284–317) |
Compounds were tested at a concentration of 50 μM.
aEach number represents one experiment conducted with gametocytaemic blood from a different mouse; ESS counts are means from sextuplicate wells.
bMean ESS counts are rounded to the nearest whole numbers.