Fig. 2.

Response of A2780 and A2780cis to Cisplatin following Acute Hypoxia. a. A2780cis were 9-fold more resistant to cisplatin in normal oxygen. b. Following acute hypoxia, A2780 cells were 8-fold more resistant to cisplatin if the treatment was also carried out in hypoxia. This was attenuated (2.4-fold) if the treatment was carried out in normoxia. c. A2780cis were approximately 2-fold more resistant to cisplatin following acute hypoxia if the treatment was carried out in hypoxia. When acutely hypoxic A2780cis were placed in normal oxygen for the treatment period, the resistance returned to the same level as cells which were never exposed to hypoxia. n = 3 *p < 0.05 ***p < 0.001