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Design matrix of hypoxia/cisplatin treatments
| Pre-treatment | Treatment Day 1 | Treatment Day 2 | Treatment Day 3 |
|---|---|---|---|
| (0 – 24 h) | (24 – 48 h) | (48 – 72 h) | |
| Normoxia | Normoxia | Normoxia | Normoxia |
| Normoxia | Hypoxia | Hypoxia | Hypoxia |
| Normoxia | Normoxia | Hypoxia | Hypoxia |
| Normoxia | Normoxia | Normoxia | Hypoxia |
| 4 hours hypoxia | Normoxia | Normoxia | Normoxia |
| 4 hours hypoxia | Hypoxia | Hypoxia | Hypoxia |
| 5 days hypoxia | Normoxia | Normoxia | Normoxia |
| 5 days hypoxia | Hypoxia | Hypoxia | Hypoxia |
