Fig. 2.

Lipoprotein profiles are altered prior to and during transition to metabolic disease. Significant differences in plasma levels of total TAG, HDLs, HDL cholesterol, HDL large particles, HDL small particles, and IDL, shown as medians and IQR in metabolic impaired (Metⁱ) and age- and weight-matched controls (Ctrl) at time of diagnosis (Dx) and 2 years prior to diagnosis (pre-Dx); n = 8 per group per time point. Variables shown are constituents of lipoprotein biomarker models (models 1 and 2). Statistical significance based on univariate analysis (two-sample Wilcoxon): * P < 0.05 for control versus impaired; Δ* P < 0.05 for difference between the changes for impaired and control animals from 2 years prior to time of diagnosis (Metⁱ_Dx-Metⁱ_pre-Dx) versus (Ctrl_Dx-Ctrl_pre-Dx).