TABLE 1.
The dissociation constants and Hill coefficients for the interaction of saquinavir with pretreated T-lymphocytes
| Treatment | Kd (μM) | Hill Coefficient |
| Untreated | 36 ± 1 | 7 ± 1 |
| 7-KC | 47 ± 1 | 9 ± 2 |
| α-TS | 52 ± 2 | 3.4 ± 0.2 |
| MβCD | 68 ± 2 | 4.4 ± 0.4 |
The dissociation constants (Kd) and Hill coefficients (±SEM) obtained from best fits of a sigmoidal binding model to the data presented in Fig. 3 for the interaction of saquinavir with T-lymphocytes, either untreated or pretreated with 7-ketocholesterol (7-KC), α-tocopherol succinate (α-TS), or methyl-β-cyclodextrin (MβCD).