Figure 3.

Putative Tolerizing Tcell epitopes found in HIV. Cytoscape can be used to illustrate the relationship between a pathogen epitope and the human genome. In this figure the source HIV Env peptide is represented as a green diamond, its constituent 9-mer epitopes as gray squares, its cross-conserved partners in the human genome as blue triangles, and the source human proteins as light purple circles. As shown in this figure, not only is the Env peptide highly conserved in a number of different human proteins, but a single cross-conserved epitope can be found in 32 alleles of the same human protein (source protein highlighted in orange).