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. 2014 Nov 1;10(11):3224–3235. doi: 10.4161/hv.29857

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© 2014 The Author(s). Published with license by Taylor & Francis Group, LLC

© Annalisa Legitimo, Rita Consolini, Alessandra Failli, Giulia Orsini, and Roberto Spisni

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — DC development. This illustration summarizes the current model of the developmental pathways of both myeloid and plasmacytoid DCs. Dashed lines indicate pathways that are likely but not yet definitively shown to operate in DC development. In humans, equivalents of mouse MDP, CDP, and pre-DC have not been found. Cytokines that are important in each transition are indicated. Abbreviations: MPP, multi potential progenitor; CMP, common myeloid progenitor; CLP, common lymphoid progenitor; MDP, macrophage DC progenitor; CDP, common DC progenitor; pre-DC, circulating DC progenitor; pDC, plasmacytoid DC; mDC, myeloid DC; Mo-DC, monocyte-derived DC.