Table 1.
Summary of large-scale miRNA sequencing papers including mESCs and hESCs. The number of samples analysed, the species and embryonic stem cell lines represented, the number of known miRNAs observed and the number of novel miRNAs found are shown. J1aza indicates J1 mESCs treated with the DNA methyltransferase inhibitor 5’-aza-deoxycytidine
| Landgraf etal.2007 [18] | Calabrese et al. 2007 [19] | Morine et al. 2008 [ 20] | Bar et al.2008 [21] | |
|---|---|---|---|---|
| #Samples | 256 | 4 | 2 | 2 |
| Species | Human, mouse, rat | Mouse | Human | Human |
| ESC samples (# reads/sample) | Male mESC (1254) | Dicer +/+ (57,834) | H9hESC (6,147,718) | H1-Undiff (280,185) |
| Female mESC (335) | Dicer −/− (54,339) | H9EB (6,014,187) | H1-Diff (143,124) | |
| J1 (149,986) | ||||
| J1aza (155,934) | ||||
| Known miRNAs | 340 human/303 mouse/205 rat | 360 | 334 | 191 |
| Novel miRNAs | 12 human/23 mouse/14 rat | 46 | 83 | 13 |