Table 2.

Characteristics of MDA-MB-231 orthotropic xenograft tumor in nude mice

Tumor characteristics	MDA-MB-231 xenograft	MDA-MB-231 xenograft + OPN siRNA
Tumor infiltration	Significant enhanced levels of infiltration	Poor infiltration
Tumor differentiation	Poorly differentiated structure, 20–40% mammary fat pad lobules	Well differentiated lobular structure
Vessel formation	High, more vWF positive	Poor, less vWF positive
Mitotic features/hpf	7–9	1–3
Tumor giant cell	Plenty	Scanty
Nuclear polymorphism	Significant nuclear size variation	Small regular and uniform nucleus