Figure 2.

Analysis of IgG2a (A–C) and IgG1-specific antibody levels (D–F) with respect to rL1, rVLP and rGST per group using ELISA. Serum samples were obtained from immunized mice after second (A & D), third (B & E) immunization and 7 days after C3 challenge (C & F). The significant increases in L1-specific IgG1 and IgG2a isotypes were observed in mice immunized with Pichia-L1, L.tar-L1 and Gardasil as compared to control groups 4 to 6 (٭P < 0.05). Data shows antibody titers of pooled mice sera with independent experiments and error bars indicate SD. N = 8 per group.