Table 2:
Peptide Abs | Proliferation % inhibition BT474/ JIMT-1 | Phosphorylation % Inhibition BT474/ JIMT-1 | ADCC % Lysis (100:1) JIMT-1 | Apoptosis Luminescense x106 BT474/ JIMT-1 | Invasion Assay JIMT-1 cells invaded |
---|---|---|---|---|---|
α-HER-2 (597) | 35/8 | pHER-2; HER-2: 10/5 IGF-1R:10/15 | 12 | 14/3 | 580 |
α-IGF-1R (56) | 12/25 | p-IGF-1R; HER-2: 7/7 IGF-1R: 20/45 | 40 | 4/14 | 550 |
α-HER-2 597 + α-IGF-1R(56) | 40/45;P<0.003 | pHER-2; 10/25; P<0.05; p-IGF-1R; 25/55; P<0.005 | 70; P<0.001 | 15/17; P<0.001 | 400; P<0.05 |