Table 3:
Peptide mimics or Peptide Abs | Proliferation % inhibition JIMT-1 /BxPC3 Peptide Mimics | Phosphorylation % Inhibition JIMT-1 /BxPC3 Peptide Mimics | ADCC %Lysis(100:1) JIMT-1 Peptide Abs | Apoptosis Luminescense x106 JIMT-1 /BxPC3 Peptide Abs | Invasion Assay JIMT-1 cells invaded Peptide Abs |
---|---|---|---|---|---|
HER-1 (418) | 25/50 P<0.005 | p-HER-1; HER-1: 20/18 IGF-1R: 18/20 | 20 P<0.001 | 4/4 P<0.001 | 800 |
IGF-1R(56) | 50/25 P<0.005 | p-IGF-1R; HER-1:30/25 IGF-1R: 30/30 | 50 P<0.001 | 8/8 P<0.001 | 800 |
HER-1(418) + IGF-1R (56) | 75/75 P<0.001 | p-HER-1; HER-1: 50/30; P<001 p-IGF-1R: IGF-1R: 40/55; P<005 | 70 P<0.001 | 12/15 P<0.001 | 500; P<0.05 |