Table 1. Major drug-resistant mutations in the HBV reverse-transcriptase (rt) resulting in structural changes in the HBsAg protein.
| Nucleos(t)ide | Pol-gene mutations | S gene mutations |
|---|---|---|
| S gene mutations | (Primary or compensatory) | |
| LMV and LdT | rtM204V | sI195M |
| rtM204I | sW196S/L/* | |
| rtV173L | sE164D | |
| ADV | rtA181T§# | sW172L/* |
| (#LMV, §LdT) | rtA181V§ | sL173F |
| ETV | rtI169T | sF161H/L |
| rtT184C | sL175F+sL176V | |
| rtT184L/S | sL175F | |
| rtT184G | sL176V | |
| rtT184M | sL176stop | |
| rtS202C/G | sS193F/L | |
| rtS202I | sV194F/S |
§,# Also induced by #LMV or §LdT; *stop codon.