Table 1.
Dynamic binding capacity and virus recovery on different chromatography supports for different virus (-like) materials
| Nanoparticle | Type | Capacity | Recovery | Reference |
|---|---|---|---|---|
| Influenza | CIM QA monolith | 2E + 10 TCID₅₀/mL | 70%–87% 42% |
11 12 |
| Mustang Q | 2E + 10 TCID₅₀/mL | 40% | 12 | |
| Q Sepharose XL | 1E + 9 TCID₅₀/mL | 24% | 12 | |
| Adenovirus 5 | Q Sepharose XL | 4E + 13 VP/mL | n/d | 4 |
| Sartobind Q | 1.5E + 13 VP/mL | 60% | 73 | |
| Canine Ad 2 (CAV2) | Fractogel EMD propyl (capture) | 4.5E + 10 VGCN/mL | 77%–100% | 8 |
| CIM DEAE monolith (polishing) | 7E + 11 viral VGCN/mL | 58%–77% | 8 | |
| Adenovirus 3 VLP | CIM QA monolith | 1.3E + 16 VP/mL | 52% | 42 |
| Lentivirus | CIM DEAE monolith | >8E + 7 IP/mL | 80% | 10 |
| Q membrane | n/d | 70% | 74 | |
| Retroviral vectors | DEAE Sepharose FF | >3E + 7 cfu/mL | 53% | 75 |
| Flavivirus | CIM QA monolith | 4.5E + 9 FFU/mL | 72% | 76 |
| Mustang Q membrane | n/d | 36% | 76 | |
| Capto Q resin | n/d | 37% | 76 | |
| Baculovirus | CIM QA monolith (capture) | 2.4E + 11 pfu/ml | up to 99% | 77 |
| Sartobind D membrane | 7.7E + 10 TP/mL | 65% | 78 | |
| Capto DEAE resin | n/d | 33% | 78 | |
| Rotavirus | CIM QA monolith | 4E + 12 VP/mL | n/d | 79 |
| Rotavirus like particle | Resource Q | n/d | 50% | 80 |
| Rotavirus like particle | Sartobind D membrane (capture) | n/d | 55% | 81 |
| Rotavirus like particle | Sartobind D membrane (concentration) | n/d | 97% | 81 |
| T7 bacteriophage | CIM QA monolith | 1E + 13 pfu/mL | 100% | 25 |
| M13 bacteriophage | CIM QA monolith | 4.5E + 13 pfu/mL | 100% | 25 |
| Lambda bacteriophage | CIM QA monolith | 1E + 13 pfu/mL | 100% | 25 |
| PRD1 bacteriophage | CIM DEAE/QA monolith | 6E + 13 pfu/ml | 60%–80% | 27 |