Figure 4.

(See previous page) Comparison of different loops, harboring key neutralizing epitopes, of 4 genotypes HPV11, HPV16, HPV18 and HPV35 (for which X-ray structures are available).⁹⁶ (A) The BC loop, DE loop, EF loop, FG loop and HI loop colored in red, green, blue, yellow and magenta, respectively, are shown in L1 monomer, pentamer and T = 7 VLP. (B) Comparison of the L1 surface loops, BC loop, DE loop, EF loop, FG loop and HI loop respectively. HPV11, HPV16, HPV18 and HPV35 are shown in different colors (blue, magenta, yellow and green, respectively). (C) Localization of the different loops in the full length of HPV16 L1 protein. The epitope regions of 2 type-specific neutralizing mAbs are labeled with an arrow (H16.V5 binding to the FG and HI loop, H11.B2 binding to the DE loop).