Table 3.
The key epitope information of neutralizing mAbs against HEV, HPV and HBV
| Virus | mAb | Epitope information | Notes | References |
|---|---|---|---|---|
| HEV | 8C11 | Glu479, Ser497, Arg512, His577, Arg578, Lys534 | Key epitopes located in the dimeric E2s domain which is formed by the P2 (aa 454–606) or P (aa 456–606) domain with hydrophobic interaction and hydrogen bond and presents a single β-barrel structure | 16 |
| 8H3 | Glu479, Tyr485, Ile529, Lys534 | 14 | ||
| MAB272 | Asp496, Gly591, Pro592 | 15 | ||
| MAB1323 | Ser487, Ser488, Thr489, Pro491, Asn562, Thr564 | 15 | ||
| Fab244 | Glu479, Asp481, Thr484, Tyr485, Ser487, Tyr532, Ser533 | 17 | ||
| HPV | V5 (HPV16) | FG loop (aa 266–297) and HI loop (aa 339–365) | Key epitopes located on the 5 flexible surface loops: BC, DE, EF, FG and HI | 20 |
| R5 (HPV18) | NA | 68 | ||
| B10.5 (HPV6) | BC loop (aa 49–54) and DE loop (aa 169–178) | 157 | ||
| B2 (HPV11) | DE loop (aa 123–141) | 73 | ||
| A6 (HPV31) | EF loop | 81 | ||
| E12 (HPV33) | DE (aa 132–140) and FG loop (aa 260–270 and aa 282–291) | 82 | ||
| O3 (HPV35) | NA | 20 | ||
| C1 (HPV45) | NA | 20 | ||
| 8D11, 9F7 (HPV52) | NA | 83 | ||
| 2C3, 6F11 (HPV58) | NA | 83 | ||
| B1.A1(BPV1) | NA | 83 | ||
| HBV | RF1 | aa 124–137 | Key epitopes are sensitive to redox treatment and are located near the dimeric interface | 113 |
| A1.2 | NA | 110 | ||
| 5F11 | NA | 111 |