Table 1. TBA and ELISA unit data from mice immunized with either Pfs25MF3E or Pfs25-FhCMB.
Study Day 42 | Study Day 168 | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Vaccine candidate | Dose (µg) | ELISA units | Prevalence a | Intensity b | % reduction c | p-value d | ELISA units | Prevalence a | Intensity b | % reduction c | p-value d |
Pfs25MF3E | 5 | 5835 | 5 | 0.1 (0–1) | 99 | < 0.001 | 4346 | 45 | 1.2 (0–11) | 96 | < 0.001 |
Pfs25MF3E | 1 | 4696 | 65 | 1.2 (0–4) | 92 | < 0.001 | 3120 | 85 | 8.7 (0–21) | 68 | < 0.05 |
Pfs25MF3E | 0.2 | 3318 | 40 | 0.9 (0–3) | 94 | < 0.001 | 4926 | 75 | 2.3 (0–6) | 92 | < 0.001 |
Pfs25-FhCMB | 5 | 7404 | 5 | 0.1 (0–1) | 99 | < 0.001 | 7180 | 10 | 0.2 (0–2) | 99 | < 0.001 |
Pfs25-FhCMB | 1 | 14923 | 10 | 0.1 (0–1) | 99 | < 0.001 | 12124 | 60 | 1.3 (0–4) | 95 | < 0.001 |
Pfs25-FhCMB | 0.2 | 4909 | 10 | 0.1 (0–1) | 99 | < 0.001 | 4180 | 85 | 7.7 (0–29) | 72 | < 0.05 |
LicKM only | 2.5 | 22 | 80 | 14.2 (0–56) | - | - | 84 | 100 | 27.6 (1–56) | - | - |
a The proportion (percentage) of mosquitoes infected; bArithmetic mean of oocysts per feeder (the range of oocysts); c% reduction = ((mean control oocyst - mean test oocyst) / mean control oocyst)*100; dSignificance when compared with the LicKM only group.