Table 4.
Adjusted comparison of the frequency of events in the EGB cohorts (whole DPP4-i class, vildagliptin, IS), considering only treatment initiations in the IS cohort
| DPP4-i N=6,701 | IS initiation N=4,005 | P-value | Vildagliptin | IS initiation N=4,005 | P-value N=1,440 | |
|---|---|---|---|---|---|---|
| Person-years of exposure | 7,062 | 6,232 | 581 | 1,704 | ||
| Number of patients admitted to hospital for hypoglycemia (%) | 8 (0.12%) | 17 (0.42%) | =0.0016 | 0 (0.0%) | 14 (0.35%) | =0.025 |
| Number of hospital admissions for hypoglycemia | 11 | 18 | 0 | 14 | ||
| Adjusted incidence rate of hospital admissions for hypoglycemia/1,000 patient-years, m (95% CI) | 1.6 (0.8; 2.8) | 2.9 (1.7; 4.6) | =0.1068 | 0.0 (0.0; 0.0) | 8.2 (4.5; 13.8) | =0.01 |
| Number of patients visiting the ED (for any reason) (%) | 704 (10.51%) | 666 (16.63%) | <0.0001 | 60 (4.20%) | 317 (7.90%) | <0.0001 |
| Number of ED visits | 937 | 960 | 77 | 410 | ||
| Adjusted incidence rate of ED visits/1,000 patient-years, m (95% CI) | 132.7 (124.3; 141.5) | 154.0 (144.5; 164.1) | =0.0012 | 132.6 (104.6; 165.6) | 240.6 (217.9; 265.1) | <0.0001 |
Abbreviations: ED, emergency department; IS, insulin secretagogues (sulfonylurea or glinide); EGB, Echantillon Généraliste des Bénéficiaires; DPP4-i, dipeptidyl peptidase 4 inhibitors; m, mean.