Table 8.

T cell immune responses in volunteers vaccinated with H2N2 LAIV or placebo

		Percent of subjects with significant increases* in virus–specific memory T cells
		CD4+		CD4+ Tcm**		CD4+ Tеm**		CD8+		CD8+ Tcm		CD8+ Tеm		Total
Time points	Test article	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI	n (%)	95% CI
Day 6 / Day 0	LAIV (n = 27)	1 (3.7)	0.7–18.3	0	0.0–12.5	0	0.0–12.5	3 (11.1)	3.9–28.1	0	0.0–12.5	0	0.0–12.5	3 (11.1)	3.9–28.1
	Placebo (n = 10)	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8
Day 28 / Day 0	LAIV (n = 27)	2 (7.4)	2.1–23.4	2 (7.4)	2.1–23.4	3 (11.1)	3.9–28.1	3 (11.1)	3.9–28.1	2 (7.4)	2.1–23.4	3 (11.1)	3.9–28.1	6 (22.2)	10.6–40.8
	Placebo (n = 10)	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8
Day 56 / Day 0	LAIV (n = 27)	3 (11.1)	3.9–28.1	3 (11.1)	3.9–28.1	1 (3.7)	0.7–18.3	1 (3.7)	0.7–18.3	1 (3.7)	0.7–18.3	3 (11.1)	3.9–28.1	6 (22.2)	10.6–40.8
	Placebo (n = 7)	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5
Day 112 / Day 0	LAIV (n = 25)	5 (20.0)	8.9–39.1	1 (4.0)	0.7–19.5	2; (8.0)	2.2–25.0	3 (12.0)	4.2–30.0	3 (12.0)	4.2–30.0	9 (36.0)	20.2–55.5	11 (44.0)	26.7–62.9
	Placebo (n = 7)	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5	0	0.0–34.5
TOTAL	LAIV (n = 27)	6 (22.2)	10.6–40.8	4 (14.8)	5.9–32.5	4 (14.8)	5.9–32.5	6 (22.2)	10.6–40.8	4 (14.8)	5.9–32.5	12 (44.4)	27.6–62.7	15 (55.6)	37.3–72.4
	Placebo (n = 10)	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8	0	0.0–27.8

*More than Placebo mean value plus 3 Standard Deviations; CI, 95% confidence interval as calculated by Wilson test;

**Tcm – central memory T cells; Tem – effector memory T cells.