Table 3.
Immunogenicity of IM-MF59 and ID influenza vaccines against homologous and heterologous drifted strains in volunteers 60 y of age and older
| Vaccine | Study | Year | N. (Age) | Antigen | % Seroprotection rate ≥60% | GMTR ≥2.0 | % Seroconversion rate ≥30% | |
|---|---|---|---|---|---|---|---|---|
| IM-MF59 | Baldo 201040 | 1998–99 | 72 [≥65] | A/Sidney/5/97* | (H3N2) | 77.8 | 5.5 | 76.4 |
| A/Wisconsin/67/05 | (H3N2) | 79.2 | 3.1 | 41.7 | ||||
| Del Giudice 200646 | 2003–04 | 60 [>60(61–91)] | A/Panama/2007/99 * | (H3N2) | 98.3 | 4.5 | na | |
| A/Wyoming/3/03 | (H3N2) | 98.3 | 6.6 | na | ||||
| Iorio 200649 | 2004–05 | 67 [84(60–99)] | A/Fujan/411/02 * | (H3N2) | 95.5 | 6.9 | 73.1 | |
| A/California/7/04 | (H3N2) | 89.5 | 4.0 | 55.2 | ||||
| Ansaldi 200835 | 2004–05 | 25 [≥65] | A/Wyoming/3/03 * | (H3N2) | 100 | 4.6 | 68 | |
| A/Panama/2007/99 | (H3N2) | 100 | 4.3 | 60 | ||||
| A/California/7/04 | (H3N2) | 80 | 2.7 | 48 | ||||
| A/Wisconsin/67/05 | (H3N2) | 64 | 2.9 | 44 | ||||
| Camilloni 201043 | 2007–08 | 67 [83(61–102)] | A/Wisconsin/67/05* | (H3N2) | 86.6 | 4.7 | 53.7 | |
| A/Brisbane/10/07 | (H3N2) | 65.7 | 4.3 | 44.8 | ||||
| Ansaldi 201037 | 2005–06 | 25 [76.68±4.76] | A/California/7/04 * | (H3N2) | 100 | 8.9 | 76 | |
| A/Wyoming/3/03 | (H3N2) | 68 | 5.3 | 56 | ||||
| A/Genova/13/04 | (H3N2) | 88 | 16.9 | 84 | ||||
| A/Genova/27/04 | (H3N2) | 92 | 10.8 | 64 | ||||
| A/Genova/47/04 | (H3N2) | 100 | 20.5 | 84 | ||||
| A/Genova/59/04 | (H3N2) | 100 | 10.3 | 76 | ||||
| A/Genova/2/05 | (H3N2) | 100 | 12.8 | 80 | ||||
| A/Genova/11/05 | (H3N2) | 100 | 20 | 80 | ||||
| A/Genova/47/05 | (H3N2) | 100 | 14.7 | 84 | ||||
| A/Genova/62/05 | (H3N2) | 100 | 13.6 | 84 | ||||
| A/Wisconsin/67/05 | (H3N2) | 100 | 12.1 | 76 | ||||
| A/Genova/3/06 | (H3N2) | 100 | 3.0 | 68 | ||||
| A/Brisbane/10/07 | (H3N2) | 96 | 14.7 | 80 | ||||
| A/Genova/2/07 | (H3N2) | 96 | 4.2 | 68 | ||||
| A/Genova/3/07 | (H3N2) | 96 | 16.2 | 72 | ||||
| Song 201355 | 2009–10 | 47 [71.2±4 .5] | A/Brisbane/10/07* | (H3N2) | 91.5 | 9.1 | 74.5 | |
| A/Wisconsin/67/05 | (H3N2) | 93.6 | 4.3 | 57.4 | ||||
| Camilloni 201457 | 2011–12 | 40 [85.3(72–98)] | A/Perth/16/09 * | (H3N2) | 87.5 | 3.3 | 47.5 | |
| A/Perugia/06/12 | (H3N2) | 70.0 | 2.1 | 27.5 | ||||
| A/Perugia/20/12 | (H3N2) | 47.5 | 2.3 | 25.0 | ||||
| A/Perugia/44/12 | (H3N2) | 67.5 | 2.5 | 37.5 | ||||
| A/Perugia/50/12 | (H3N2) | 82.5 | 2.3 | 25.0 | ||||
| ID | Ansaldi 201258 | 2006–07 | 25 [68±7 ] | A/Wisconsin/67/05* | (H3N2) | 88 | 4.5 | 60 |
| A/Brisbane/10/07 | (H3N2) | 68 | 3.7 | 52 | ||||
| A/Genova/62/05 | (H3N2) | 88 | 3.0 | 48 | ||||
| A/Genova/3/07 | (H3N2) | 72 | 3.5 | 56 | ||||
| A/Genova/2/07 | (H3N2) | 68 | 2.3 | 32 | ||||
| A/Genova/3/06 | (H3N2) | 60 | 2.3 | 36 | ||||
| Camilloni 201457 | 2011–12 | 40 [84.6(64–100)] | A/Perth/16/09 * | (H3N2) | 92.5 | 4.6 | 60.0 | |
| A/Perugia/06/12 | (H3N2) | 82.5 | 2.4 | 35.0 | ||||
| A/Perugia/20/12 | (H3N2) | 72.5 | 2.1 | 17.5 | ||||
| A/Perugia/44/12 | (H3N2) | 87.5 | 2.0 | 25.0 | ||||
| A/Perugia/50/12 | (H3N2) | 90.0 | 2.3 | 20.0 | ||||
| IM-MF59 | Baldo 201040 | 1998–99 | 72 [≥65] | A/Beijing/262/95* | (H1N1) | 100 | 8.7 | 94.4 |
| A/New Cal/20/99 | (H1N1) | 87.5 | 6.1 | 68.1 | ||||
| Camilloni 201043 | 2007–08 | 67 [83(61–102)] | A/Solomon Isl/3/06* | (H1N1) | 71.6 | 5.2 | 59.7 | |
| A/Brisbane/59/07 | (H1N1) | 56.7 | 3.2 | 38.8 | ||||
| Song 201355 | 2009–10 | 47 [71.2±4 .5] | A/Brisbane/59/2007* | (H1N1) | 91.5 | 4.1 | 55.3 | |
| A/California/7/09 | (H1N1) | 14.9 | 1.1 | 6.3 | ||||
| A/New Cal/20/99 | (H1N1) | 31.9 | 1.9 | 12.8 | ||||
| A/Solomon Isl/3/06 | (H1N1) | 78.7 | 2.2 | 25.5 | ||||
| ID | Ansaldi 201359 | 2010–11 | 28 [76.9±8.4] | A/California/7/09* | (H1N1) | 63 | 3.4 | 50 |
| A/Genova/1/11 | (H1N1) | 79 | 4.1 | 63 | ||||
| A/Genova/6/11 | (H1N1) | 79 | 4.8 | 67 | ||||
| A/Genova/24/11 | (H1N1) | 75 | 2.8 | 42 | ||||
| IM-MF59 | Baldo 201040 | 1998–99 | 72 [≥65] | B/Beijing/184/93* | (B) | 100 | 3.8 | 66.7 |
| B/Malaysia/2506/04 | (B) | 69.4 | 2.0 | 25 | ||||
| Camilloni 200942 | 2003–04 | 91 [82 (63–98)] | B/HongKong/330/01* | (B) | 81.3 | 1.8 | na | |
| B/Malaysia/2506/04 | (B) | 86.8 | 1.9 | na | ||||
| B/Sichuan/379/99 | (B) | 96.7 | 1.7 | na | ||||
| B/Shangai/361/02 | (B) | 52.7 | 1.7 | na | ||||
| Camilloni 201043 | 2007–08 | 67 [83(61–102)] | B/Malaysia/2506/04* | (B) | 58.2 | 2.4 | 26.9 | |
| B/Florida/4/06 | (B) | 68.6 | 1.9 | 23.9 | ||||
* vaccine strain.