Figure 4.

Diagram representing (A) the relative ratio of surface targets that are accessible for humoral and cytotoxic immunity, and the remaining cellular content that is undesired for preparation of cell-based vaccines; and (B) the effects of trypsin impurities and cell death rates on the preparation of cell surface antigens. The lighter region in the lower left corner represents conditions where cell-surface antigen preparations are compatible with the preparation of SANTAVAC vaccines. Trypsin purity is reflected by the levels of enzymatic activity. Adapted from Lokhov.⁴⁰