Table 3.
Clinic pathological characteristics of HPV-positive and HPV-negative patients with ESCC
| Characteristics | Number | HPV+ Patients n = 204 | HPV− Patients n = 112 | χ 2 | P value |
|---|---|---|---|---|---|
| n (%) | n (%) | ||||
| Age (years), mean ± SD | 316 | 53.01 ± 8.202 | 52.67 ± 10.141 | 0.746a | |
| Age (years) | 0.301 | 0,584 | |||
| <55 | 173 | 114 (65.9) | 59 (34.1) | ||
| ≥55 | 113 | 90 (62.9) | 53 (37.1) | ||
| Gender | 2.692 | 0,101 | |||
| Male | 187 | 127 (67.9) | 60 (32.1) | ||
| Female | 129 | 76 (58.9) | 53 (41.1) | ||
| Smoking | 0.081 | 0.775 | |||
| Yes | 82 | 54 (65.9) | 28 (34.1) | ||
| No | 234 | 150 (64.1) | 84 (35.9) | ||
| Drinking | 2.149 | 0.143 | |||
| Yes | 65 | 47 (72.3) | 18 (27.7) | ||
| No | 251 | 157 (62.5) | 94 (37.5) | ||
| Location of the tumor | 1.311 | 0.519 | |||
| The upper thoracic portion | 19 | 10 (52.6) | 9 (47.4) | ||
| The mid-thoracic portion | 170 | 112 (65.9) | 58 (34.1) | ||
| The lower thoracic portion | 127 | 82 (64.6) | 45 (35.4) | ||
| Histologic grade | 0.331 | 0.848 | |||
| Well-differentiated (G1) | 106 | 67 (63.2) | 39 (36.8) | ||
| Moderately differentiated (G2) | 162 | 107 (66.0) | 55 (34.0) | ||
| Poorly differentiated (G3) | 48 | 30 (62.5) | 18 (37.5) | ||
| Depth of invasion | 0320 | 0.572 | |||
| T1/T2 | 188 | 119 (63.3) | 69 (36.7) | ||
| T3/T4 | 128 | 85 (66.4) | 43 (33.6) | ||
| Lymph node metastasis | 1.127 | 0.288 | |||
| No | 193 | 129 (66.8) | 64 (33.2) | ||
| Yes | 123 | 75 (61.0) | 48 (39.0) | ||
| Clinical stage | 1.847 | 0.174 | |||
| stage I/II | 231 | 144 (62.3) | 87 (37.7) | ||
| stage III/IV | 85 | 60 (70.6) | 25 (29.4) |
aStudent’s test