Table 4. Cytokine production and disease characteristics.

	TNF-α [IQR]	P value	IL-1β [IQR]	P value	IL-6 [IQR]	P value	IL-10 [IQR]	P value
HC (n = 24)	428 [267–468]		679 [565–878]		2687 [1830–3228]		80 [61–149]
Localization
L1 (n = 33)	454 [362–624]		561 [356–903]		2384 [1585–3017]		89 [65–107]
L2 (n = 8)	516 [469–560]		603 [237–1243]		2715 [1701–3465]		64 [30–83]
L3 (n = 28)	421 [354–561]	0.41	568 [387–750]	0.90	2395 [1756–2830]	0.79	81 [55–112]	0.22
P—(n = 48)	452 [368–573]		569 [380–901]		2384 [1711–2872]		88 [64–111]
P + (n = 21)	483 [325–575]	0.98	560 [272–747]	0.58	2491 [1469–3332]	0.92	75 [55–107]	0.32
Behavior
No fistulas (n = 31)	454 [400–563]		561 [384–905]		2417 [1707–2816]		79 [55–107]
Fistulas (n = 38)	462 [350–579]	0.55	568 [298–813]	0.62	2351 [1567–3305]	0.81	82 [62–108]	0.50
No strictures (= 25)	408 [351–584]		511 [254–859]		2402 [1691–3062]		90 [67–114]
Strictures (n = 44)	476 [387–573]	0.38	569 [400–866]	0.45	2384 [1703–3049]	0.92	77 [54–107]	0.12
Extra intestinal manifestations
No arthralgia (n = 51)	454 [373–578]		577 [379–902]		2445 [1706–3045]		85 [62–106]
Arthralgia (n = 18)	476 [348–562]	0.90	550 [261–796]	0.51	2204 [1588–3088]	0.46	82 [53–124]	0.77

Cytokine levels (pg/ml) are presented as medians with the interquartile range [IQR]. HC, Healthy control; TNF-α, Tumor necrosis factor alpha; IL, Interleukin; L1, ileal disease; L2, colonic disease; L3, ileocolonic disease; P-, no peri-anal disease; P+, peri-anal disease; IQR, interquartile range.