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. Author manuscript; available in PMC: 2015 Jul 24.
Published in final edited form as: Curr Pharm Des. 2014;20(23):3738–3750. doi: 10.2174/13816128113196660740

Fig. 2. Effect of C(-1019)G polymorphism rs6295 on 5-HT1A receptor expression.

Fig. 2

A simplistic model of the C(-1019)G change (labeled C or G), which prevents Deaf1 from recognizing its element on the 5-HT1A promoter, is presented. In 5-HT neuronal cells, Deaf1 represses 5-HT1A receptor transcription, but in certain non-serotonergic neurons it oppositely enhances 5-HT1A expression. An upregulation of 5-HT1A autoreceptor (Auto) expression in raphe neurons is predicted for the G(-1019) allele based on loss of Deaf1-mediated repression presynaptically. Conversely, in some non-serotonergic neurons a reduction in 5-HT1A heteroreceptor (Hetero) expression is predicted based on the loss of Deaf1 enhancer activity.