Skip to main content
. Author manuscript; available in PMC: 2015 Jul 24.
Published in final edited form as: Curr Pharm Des. 2014;20(23):3738–3750. doi: 10.2174/13816128113196660740

Fig. 4. HTR1A promoter alignment.

Fig. 4

Nucleotide alignment of the human (H), mouse (M) and rat (R) 5-HT1A promoter sequence is shown ending at the translational initiation ATG codon (yellow). Sequence counts are shown at right, matches are in blue, and gaps shown by dashes. A potential alternately spliced non-coding exon is shown in red. Boxes depict the proximal promoter elements (Sp1, MAZ), NFkB sites, negative glucocorticoid receptor element (nGRE), raphe-specific Pet-1 elements (PET-1), and the repressor elements for Freud-1 and Freud-2 (DRE) and REST/NRSF (RE-1); palindrome Deaf1 elements (Palindrome) for human (H), mouse M) and rat R), TATA-box and CCAAT box. Highlighted are the human C(-1019)G polymorphism (C/G) and the rat transcription start site (R-TSS). The % nucleotide identity (human vs. mouse) over the initial 800 bp was 73%. Alignment was obtained from the Ensembl database.