Table 2.
Circulating miRNAs as prognostic biomarkers for cardiovascular disease
| Circulating miRNAs |
Outcome parameter | Expression associated with poor outcome |
References |
|---|---|---|---|
| miR-10 | Allograft rejection after heart transplantation |
Down- regulation |
[72] |
| miR-16 | LV contractility at 6 months post-MI |
Up-regulation | [88] |
| miR-27a | LV contractility at 6 months post-MI |
Up-regulation | [88] |
| miR-29a | LVEDV at 90 days post-MI | Up-regulation | [138] |
| miR-31 | Allograft rejection after heart transplantation |
Up-regulation | [72] |
| miR-34a | HF within 1 year post-MI | Up-regulation | [139] |
| Mortality or HF within 6 months post-MI |
Up-regulation | [89] | |
| LVEDD at 1 year post-MI | Up-regulation | [139] | |
| LVEDV at 6 months post-MI | Up-regulation | [89] | |
| miR-92a | Allograft rejection after heart transplantation |
Up-regulation | [72] |
| miR-101 | LV contractility at 6 months post-MI |
Down-regulation | [88] |
| miR-126 | Incident MI within 10 years | Up-regulation | [140] |
| miR-133a | All-cause mortality within 6 months after ACS |
Up-regulation | [84] |
| MACE within 6 months post-MI | Up-regulation | [85] | |
| miR-133b | Early myocardial injury and recovery after heart transplantation |
Up-regulation | [141] |
| miR-134 | Cardiac death or HF within 6 months post-MI |
Up-regulation | [135] |
| miR-150 | LVEDV post-MI | Down- regulation |
[86] |
| LV contractility at 6 months post-MI |
Down- regulation |
[88] | |
| Survival in PAH | Down- regulation |
[73] | |
| miR-155 | Cardiac death within 1 year post-MI |
Up-regulation | [142] |
| Allograft rejection after heart transplantation |
Up-regulation | [72] | |
| miR-192 | HF within 1 year post-MI | Up-regulation | [139] |
| miR-194 | HF within 1 year post-MI | Up-regulation | [139] |
| LVEDD at 1 year post-MI | Up-regulation | [139] | |
| miR-197 | Incident MI within 10 years | Down- regulation |
[140] |
| miR-208b | Mortality or HF within 30 days post-MI |
Up-regulation | [58] |
| Mortality or HF within 6 months post-MI |
Up-regulation | [89] | |
| LVEDV at 6 months post-MI | Up-regulation | [89] | |
| All-cause mortality within 6 months after ACS |
Up-regulation | [84] | |
| miR-223 | Incident MI within 10 years | Down- regulation |
[140] |
| miR-328 | Cardiac death or HF within 6 months post-MI |
Up-regulation | [135] |
| miR-380* | Cardiac death within 1 year post-MI |
Up-regulation | [142] |
| miR-499-5p | Mortality or HF within 30 days post-MI |
Up-regulation | [58] |
| miR-652 | Readmission for HF post-ACS | Down- regulation |
[87] |
| miR-1202 | Response to LVAD therapy | Up-regulation | [71] |
ACS, Acute coronary syndrome; HF, heart failure; LV, left ventricle; LVAD, left ventricular assist device; LVEDD, left ventricular end-diastolic dimension; LVEDV, left ventricular end-diastolic volume; MACE, major cardiovascular event; MI, myocardial infarction; PAH, pulmonary arterial hypertension.