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. Author manuscript; available in PMC: 2016 Jun 20.
Published in final edited form as: Am J Nephrol. 2015 Jun 20;41(0):392–399. doi: 10.1159/000433568

Figure 3. Effects of pre-treatment with N-acetylcysteine on brodifacoum-induced early hemoglobinuria and hematuria.

Figure 3

The following number of animals was treated with 0.4 BDF and NAC: 10 mg/kg/day n=8; 30 mg/kg/day n=7; 100 mg/kg/day n=9; BDF-only rats n=16.

A – rats were pre-treated with N-acetylcysteine (NAC) for 24 hours prior to 0.4 mg/kg brodifacoum (BDF) administration in the doses shown. Treatment with NAC was continued at the same doses until the end of the studies. Hemoglobinuria was detected by DiaScreen reagent strip (dipstick).

B – effects of NAC on BDF-induced changes in hematocrit. Rats were pretreated with NAC for 24 hours prior to 0.4 mg/kg BDF administration.

C – effects of NAC on 0.4 mg/kg BDF-associated hematuria. Animals were treated with NAC for the duration of the studies in the doses shown.