Table 3.

Longitudinal analyses. Regression coefficients for the modified Framingham risk score × time (in years) interaction terms from mixed-effect models testing associations with global and domain-specific cognitive measures and CDR sum-of-boxes.

	Model 1		Model 2		Model 3
	Adjusted for Education only		Adjusted for Education, Age, APOE		Adjusted for Education, Age, APOE, history of stroke/TIA
Outcome	Est [95%CI]	P	Est [95%CI]	P	Est [95% CI]	P
MMSE	−0.008 [−0.012 −0.004]	<.001	0.000 [−0.006 0.006]	0.977	0.000[−0.006 0.006]	0.988
Trails B test	0.122 [0.042 0.201]	0.003	−0.029 [−0.133 0.075]	0.583	−0.019 [−0.123 0.085]	0.718
Logical Memory, immediate recall	−0.015 [−0.023 −0.007]	<.001	0.003 [−0.008 0.014]	0.614	0.004 [−0.007 0.015]	0.520
Logical Memory, delayed recall	−0.019 [−0.028 −0.010]	<.001	0.004 [−0.008 0.016]	0.500	0.005 [−0.007 0.017]	0.398
Digit-span forward	−0.001 [−0.003 0.001]	0.325	0.001 [−0.002 0.004]	0.589	0.001 [−0.002 0.004]	0.571
Digit-span backward	−0.004 [−0.006 −0.001]	0.003	−0.001 [−0.005 0.002]	0.430	−0.001 [−0.004 0.002]	0.571
WAIS Digit Symbol	−0.060 [−0.076 −0.045]	<.001	−0.032 [−0.053 −0.011]	0.002	−0.032 [−0.053 −0.010]	0.004
Boston Naming Test	−0.013 [−0.018 −0.008]	<.001	−0.008 [−0.015 −0.000]	0.038	−0.007 [−0.014 −0.000]	0.046
CDRSUM	0.008 [0.005 0.011]	<.001	0.001 [−0.002 0.005]	0.497	0.001[−0.003 0.005]	0.554