Skip to main content
. 2015 Jul 24;10(7):e0133997. doi: 10.1371/journal.pone.0133997

Fig 3. The effect of the DAX-1 V385L variant on AR function.

Fig 3

A WT or mutant DAX-1 expression vector was cotransfected with an AR expression vector and a testosterone-inducible pMMTV-LUC plasmid into HeLa cells, and luciferase activity was measured with or without testosterone treatment. Compared with the WT and the other mutants, the DAX-1 V385L mutant failed to repress the transcriptional activity of AR in the presence of testosterone. The results are presented as the fold-change of testosterone treated relative to that in the vehicle-treated control. NC: pcDNA3.1-HA were cotransfected with an AR expression vector and a testosterone-inducible pMMTV-LUC plasmid into HeLa cells. (* p < 0.05).