Fig 3. The miR-462 and miR-731 in teleost fish are orthologues of miR-191 and miR-425, respectively, in higher vertebrates.

Diagram of the genomic location of the (A) miR-462 cluster in zebrafish and (B) the miR-191 cluster in humans. Although the diagram represents the zebrafish and human genome regions, the location of the miRNA clusters is similar to that in other teleost fish genomes and some higher vertebrate genomes, as discussed in the text. (C) Alignment of pre-miRNA sequences from various vertebrate species. The location of the mature antisense miRNA including the conserved seed region is highlighted below the alignments. hsa = Homo sapiens (human), bta = Bos taurus (cow), rno = Rattus norvegius (rat), mmu = Mus musculus (mouse), mdo = Monodelphis domestica (opossum), xtr = Xenopus tropicalis (frog), and dre = Danio rerio (Zebrafish). See S2 Fig for an alignment including more species.