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. 2015 Jul 24;10(7):e0133791. doi: 10.1371/journal.pone.0133791

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© 2015 Bennett et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — Previously published array data on young animals (6) was compared with current data to generate a heat map of top 100 differentially expressed/enriched genes between Old/Young WT (A) and Old/Young AhR-KO (B). (C) Heatmap showing array data for all ages examined. Subsequent analyses focused on genes that require both age and lack of AhR to display differential expression. 203 genes were found to be dependent on lack of AhR and aging, and included 141 up-regulated and 62 down-regulated genes. Overlap of gene changes that occurred in Old/Young WT and Old/Young AhR-KO (D = up-regulated genes, E = down-regulated genes).