Fig 5. LT-HSCs from AhR-KO mice display alterations in gene expression: LT-HSCs from aged AhR-KO and WT mice were sorted and analyzed for changes in gene expression using qPCR.

Genes analyzed were chosen based on their differential expression being dependent on aging as well as lack of AhR expression. The most significant alterations observed were in expression of PDGF-D, Smo, Wdfy1, Zbtb37 and Zfp382. N = 4 each group. A fold change of at least 1.5 was considered significant. Data are fold change values in AhR-KO calculated relative to WT using GAPDH for normalization.