Fig 1. Effect of simvastatin on fibulin-2 mRNA (A) and protein (B) levels in human coronary artery SMCs.

Cells were treated with simvastatin for 24 hours. Blot bands were normalized to actin and quantified with Quantity One Analysis Software version 4.6.2. A representative Western blot is shown. The results are shown as the mean with the standard error of the mean (SEM) for eight independent experiments in 1A (2 with cell lot number 4C0915, 3 with cell lot number 4C1284, and 3 with cell lot number 886619) and six independent experiments in 1B (2 with cell lot number 4C0915, 2 with cell lot number 4C1284, and 2 with cell lot number 886619). Comparisons were performed using ANOVA followed by Dunett post-test correction.