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. 2015 Jul 24;10(7):e0133362. doi: 10.1371/journal.pone.0133362

Fig 4. Effect of satiety factor infusions on serum levels of human MIC-1/GDF15.

Fig 4

(A) Subjects receiving CCK-8 infusion alone had significant time dependent increase in serum levels of MIC-1/GDF15 with significant increases at 120, 150 and 180 minutes of infusion. Infusion of GLP-1 or CCK plus GLP-1 had no significant effect on serum MIC-1/GDF15 level (n = 9, vehicle vs GLP-1, p = 0.2; vehicle vs CCK-8 + GLP-1, p = 0.06). (B) PYY1-36 or PYY3-36 or saline was infused in subjects that were fasted overnight and had a 310-Kcal meal. Neither PYY1-36 nor PYY3-36 infusions had a significant effect on serum MIC-1/GDF15 levels (n = 8, vehicle vs PYY1-36, p = 0.18; vehicle vs PYY3-36, p = 0.34). Data were analysed by ANOVA with Bonferroni correction and are presented as mean ± s.e.m. * represents p < 0.05.