Table 3. Study Summary of Fate and Immune Status Relevant to B. anthracis Challenge on Day 70.
IgG anti- PA (μg/mL) Geometric Mean ± C.I. | TNA ED50 Geometric Mean ± C.I. | ||||
---|---|---|---|---|---|
Test Group (μg rPA) | Survival (Alive/Total) | Day 42 | Day 65 | Day 42 | Day 65 |
Naïve Control | 0% (0/10) | 15 (15, 15) a | 17 (12, 24) | 1 (1, 1) b | 1 (1, 1) |
Vehicle Control (0 μg rPA) | 0% (0/10) | 15 (15, 15) | 15 (15, 15) | 1 (1, 1) | 1 (1, 1) |
wtrPA 10 | 100% (9/9) | 869(674, 1121) | 303(240, 381) | 27324(18802, 39709) | 6608(4522, 9656) |
wtrPA 2.5 | 90% (9/10) | 456(325, 640) | 190(136, 264) | 17670(11320, 27583) | 4282(2310, 7937) |
wtrPA0.625 | 80% (8/10) | 234(182, 301) | 78(61, 99) | 8992(6394, 12644) | 1176(499, 2773) |
mrPA 10 | 100% (9/9) | 1008(800, 1271) | 416(338, 512) | 37725(20959, 67903) | 13,437(7561, 23882) |
mrPA 2.5 | 100% (10/10) | 800(553, 1158) | 306(217, 432) | 22176(14214, 34598) | 8695(4706, 16065) |
mrPA 0.625 | 100% (10/10) | 456(335, 621) | 159(114, 224) | 13674(9504, 19676) | 2947(1366, 6358) |
AVA | 100% (10/10) | 974(802, 1183) | 363(298, 443) | 17523(10933, 28085) | 4798(2975, 7737) |
aLower limit of quantitation < 30 μg/mL.
bSamples which returned an incalculable ED50 (by Gen 5 software) were assigned an ED50 value of 1.