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. 2015 Jul 24;10(7):e0130952. doi: 10.1371/journal.pone.0130952

Table 3. Study Summary of Fate and Immune Status Relevant to B. anthracis Challenge on Day 70.

IgG anti- PA (μg/mL) Geometric Mean ± C.I. TNA ED50 Geometric Mean ± C.I.
Test Group (μg rPA) Survival (Alive/Total) Day 42 Day 65 Day 42 Day 65
Naïve Control 0% (0/10) 15 (15, 15) a 17 (12, 24) 1 (1, 1) b 1 (1, 1)
Vehicle Control (0 μg rPA) 0% (0/10) 15 (15, 15) 15 (15, 15) 1 (1, 1) 1 (1, 1)
wtrPA 10 100% (9/9) 869(674, 1121) 303(240, 381) 27324(18802, 39709) 6608(4522, 9656)
wtrPA 2.5 90% (9/10) 456(325, 640) 190(136, 264) 17670(11320, 27583) 4282(2310, 7937)
wtrPA0.625 80% (8/10) 234(182, 301) 78(61, 99) 8992(6394, 12644) 1176(499, 2773)
mrPA 10 100% (9/9) 1008(800, 1271) 416(338, 512) 37725(20959, 67903) 13,437(7561, 23882)
mrPA 2.5 100% (10/10) 800(553, 1158) 306(217, 432) 22176(14214, 34598) 8695(4706, 16065)
mrPA 0.625 100% (10/10) 456(335, 621) 159(114, 224) 13674(9504, 19676) 2947(1366, 6358)
AVA 100% (10/10) 974(802, 1183) 363(298, 443) 17523(10933, 28085) 4798(2975, 7737)

aLower limit of quantitation < 30 μg/mL.

bSamples which returned an incalculable ED50 (by Gen 5 software) were assigned an ED50 value of 1.