Table 6. Summary of Recovery of B. anthracis from Select Tissues of Inhalational Spore Challenged New Zealand White Rabbits.

Dose a		Lung	Liver	Spleen	TBLN
Naïve Control	Mean b	7.13	6.25	6.00	6.87
	SD	—	0.600	1.293	0.408
	GeoM c	1.34 x 107	1.79 x 106	9.94 x 105	7.38 x 106
	N	1	10	10	10
Vaccinated Control	Mean	8.08	6.33	6.24	6.81
	SD	—	1.118	1.314	0.563
	GeoM	1.20 x 108	2.14 x 106	1.75 x 106	6.41 x 106
	N	1	10	10	10
wtrPA 10 mg	Mean	3.29	BDL	BDL d	BDL
	SD	—	BDL	BDL	BDL
	GeoM	1.95 x 103	BDL	BDL	BDL
	N	1	10	10	10
wtrPA 2.5 mg (2.5 mg)	Mean	2.51	BDL	0.22	0.75
	SD	1.585	BDL	0.700	1.022
	GeoM	3.24 x 102	BDL	6.65 x 10−1	4.57 x 100
	N	7	10	10	10
wtrPA 0.625 mg	Mean	5.56	0.72	1.05	1.38
	SD	3.916	1.917	2.393	2.639
	GeoM	3.59 x 105	4.28 x 100	1.02 x 101	2.31 x 101
	N	2	10	10	10
mrPA 10 mg	Mean	2.03	0.26	BDL	0.35
	SD	1.755	0.835	BDL	0.744
	GeoM	1.05 x 102	8.37E-01	BDL	1.25 x 100
	N	3	10	10	10
mrPA 2.5 mg	Mean	3.40	BDL	BDL	0.40
	SD	—	BDL	BDL	0.853
	GeoM	2.49 x 103	BDL	BDL	1.53 x 100
	N	1	10	10	10
mrPA 0.625	Mean	2.67	BDL	BDL	0.23
	SD	0.005	BDL	BDL	0.736
	GeoM	4.71 x 102	BDL	BDL	7.09 x 10−1
	N	2	10	10	10
AVA (human dose)	Mean	3.01	BDL	BDL	0.17
	SD	0.761	BDL	BDL	0.543
	GeoM	1.03 x 103	BDL	BDL	4.85E-01
	N	3	10	10	10

^aTreatment = Dose delivered intramuscularly (IM) on Days 0 and 28 in 0.5 mL volume

^bMean = Log₁₀ (CFU/g + 1)

^cGeometric mean of CFU/g

^dBDL = Below detection limit (< 68–70 CFU/g)