Table 7. Incidence of Pulmonary Microscopic Findings in the Lungs of B. anthracis Spore Exposed Rabbits by Group (values represent the number of animals within a study group that possessed the finding).
| Group (μg) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Number of Animals on Study: | Naïve Control | Vehicle Control | *wtrPA 10 | wtrPA 2.5 | wtrPA 0.615 | mrPA 10 | mrPA 2.5 | mrPA 0.625 | AVA |
| 10 | 10 | 10 | 10 | 10 | 9 | 10 | 10 | 10 | |
| LUNG(S) | |||||||||
| # Examined | 10 | 10 | 10 | 10 | 10 | 9 | 10 | 10 | 10 |
| # Within Normal Limits | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Congestion | 9 | 10 | 9 | 10 | 10 | 8 | 10 | 10 | 9 |
| Minimal 1 | 0 | 0 | 3 | 3 | 2 | 1 | 1 | 0 | 1 |
| Mild 2 | 1 | 1 | 3 | 5 | 6 | 4 | 6 | 5 | 4 |
| Moderate 3 | 8 | 9 | 3 | 1 | 1 | 3 | 3 | 4 | 2 |
| Severe 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Hemorrhage | 0 | 4 | 0 | 1 | 3 | 1 | 0 | 0 | 1 |
| Minimal 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| Mild 2 | 0 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
| Moderate 3 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 | 0 |
| Edema | 9 | 6 | 0 | 1 | 4 | 0 | 0 | 0 | 0 |
| Minimal 1 | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Mild 2 | 4 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Moderate 3 | 3 | 2 | 0 | 1 | 2 | 0 | 0 | 0 | 0 |
| Bacteremia | 10 | 10 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Mild 2 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Moderate 3 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Severe 4 | 6 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| nfiltration, Heterophils, Fibrin, | |||||||||
| ±Necrotic Cell Debri; Interstitium; Capillary | 10 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Minimal 1 | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mild 2 | 3 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Moderate 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Increased; Mucosa Associated Lymphoid Tissue | 0 | 0 | 9 | 10 | 8 | 8 | 10 | 10 | 10 |
| Minimal 1 | 0 | 0 | 3 | 2 | 2 | 5 | 3 | 4 | 2 |
| Mild 2 | 0 | 0 | 5 | 8 | 6 | 3 | 7 | 5 | 7 |
| Moderate 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
| Infiltration, Lymphocytic, | |||||||||
| Histiocytic; Interstitium | 0 | 1 | 7 | 9 | 10 | 8 | 9 | 8 | 9 |
| Minimal 1 | 0 | 0 | 6 | 3 | 3 | 4 | 5 | 5 | 4 |
| Mild 2 | 0 | 1 | 1 | 5 | 5 | 4 | 4 | 2 | 5 |
| Moderate 3 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 0 |
| Accumulation; Alveolus; Macrophage | 0 | 0 | 5 | 8 | 6 | 6 | 6 | 7 | 5 |
| Minimal 1 | 0 | 0 | 4 | 4 | 1 | 6 | 5 | 5 | 4 |
| Mild 2 | 0 | 0 | 0 | 3 | 4 | 0 | 1 | 1 | 1 |
| Moderate 3 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
| Inflammation, Heterophils; | |||||||||
| Peribronchiolar; Lymphatic | 0 | 4 | 2 | 5 | 6 | 2 | 2 | 4 | 2 |
| Minimal 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 3 | 1 |
| Mild 2 | 0 | 3 | 1 | 3 | 3 | 1 | 0 | 1 | 1 |
| Moderate 3 | 0 | 1 | 0 | 2 | 3 | 0 | 0 | 0 | 0 |
| Inflammation, Granulomatous; | |||||||||
| Lymphatic; Interstitium | 0 | 0 | 2 | 6 | 4 | 1 | 1 | 1 | 3 |
| Minimal 1 | 0 | 0 | 2 | 4 | 0 | 1 | 1 | 0 | 1 |
| Mild 2 | 0 | 0 | 0 | 2 | 3 | 0 | 0 | 0 | 2 |
| Moderate 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Severe 4 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Abscess | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 0 |
| Mild 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
| Moderate 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Inflammation, Lymphocytic, Histiocytic; Pleura | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Mild 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Inflammation, Histiocytic, Heterophilic; Alveolus | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| Moderate 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Severe 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
| Bacteria; Lymphatic; Alveolus | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
| Moderate 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Severe 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
*Rabbit included that was euthanized post exposure (9h) due to causes unrelated to treatment. All pathology findings were within normal ranges.