Table 2. Top differentially expressed genes in fatal asthma- vs. non-asthma-derived ASM at baseline.
FPKM = fragments per kilobase of transcript per million mapped reads. All genes in list have q-value = 1.92E-03, magnitude Log2(Fold Change) >1.30, and at least two individual samples with FPKM >5.
| Gene | Locus | Mean FPKM Non-Asthma | Mean FPKM Fatal Asthma | Log2[Fold Change] |
|---|---|---|---|---|
| SERPINB2 | chr18:61554938–61571124 | 0.41 | 39.18 | 6.57 |
| FOS | chr14:75745480–75748937 | 56.13 | 0.66 | -6.42 |
| HBD | chr11:5254058–5255858 | 0.94 | 24.31 | 4.70 |
| EGR1 | chr5:137801180–137805004 | 232.04 | 11.36 | -4.35 |
| MYH11 | chr16:15737123–15950887 | 8.15 | 0.46 | -4.14 |
| CHI3L1 | chr1:203148058–203155922 | 57.11 | 4.21 | -3.76 |
| SFRP2 | chr4:154701741–154710228 | 7.44 | 0.63 | -3.57 |
| DES | chr2:220283098–220291461 | 13.82 | 1.29 | -3.42 |
| HLA-C | chr6:31236525–31239913 | 18.62 | 1.85 | -3.33 |
| EGR2 | chr10:64571755–64578927 | 2.99 | 0.36 | -3.07 |
| IFI6 | chr1:27992571–27998724 | 57.11 | 461.09 | 3.01 |
| IFI27 | chr14:94577078–94583033 | 8.88 | 65.13 | 2.88 |
| A2M | chr12:9217772–9268558 | 341.16 | 46.75 | -2.87 |
| EGR3 | chr8:22545173–22550815 | 3.72 | 0.54 | -2.79 |
| SCUBE3 | chr6:35182189–35218609 | 1.02 | 6.94 | 2.76 |
| TINAGL1 | chr1:32042085–32053287 | 1.69 | 10.99 | 2.70 |
| PDLIM3 | chr4:186421814–186456712 | 4.63 | 0.73 | -2.67 |
| SYPL2 | chr1:110009099–110024764 | 1.14 | 7.03 | 2.63 |
| RARRES1 | chr3:158414896–158450275 | 119.42 | 20.05 | -2.57 |
| PSG4 | chr19:43696853–43709790 | 23.85 | 138.94 | 2.54 |
| SOCS3 | chr17:76352858–76356158 | 111.55 | 20.00 | -2.48 |
| APOE | chr19:45409038–45412650 | 99.29 | 18.03 | -2.46 |
| B4GALNT4 | chr11:369794–382117 | 7.42 | 1.41 | -2.39 |
| TM4SF20 | chr2:228226873–228244022 | 0.75 | 3.93 | 2.38 |
| NPAS1 | chr19:47524142–47549017 | 0.69 | 3.51 | 2.35 |
| JUNB | chr19:12902309–12904125 | 132.22 | 26.05 | -2.34 |
| PTGS2 | chr1:186640943–186649559 | 5.40 | 1.06 | -2.34 |
| MX1 | chr21:42792519–42831141 | 3.79 | 18.85 | 2.32 |
| IL8 | chr4:74606222–74609433 | 0.87 | 4.31 | 2.31 |
| PPP1R1B | chr17:37783176–37792878 | 7.63 | 1.54 | -2.31 |
| IGFBP7 | chr4:57845108–58071465 | 141.30 | 673.27 | 2.25 |
| ACTG2 | chr2:74120092–74146780 | 41.93 | 8.95 | -2.23 |
| HLA-B | chr6:31321648–31324989 | 42.92 | 9.34 | -2.20 |
| TEK | chr9:27109146–27230172 | 1.28 | 5.82 | 2.19 |
| OXTR | chr3:8792094–8811300 | 5.32 | 23.54 | 2.15 |
| SCN4B | chr11:118004091–118023630 | 4.44 | 1.01 | -2.14 |
| CCL13 | chr17:32683470–32685629 | 1.31 | 5.62 | 2.10 |
| NDNF | chr4:121956781–121993673 | 4.00 | 0.96 | -2.06 |
| TFAP2A | chr6:10396915–10419797 | 1.73 | 7.13 | 2.05 |
| NR4A1 | chr12:52416615–52453291 | 17.27 | 4.21 | -2.04 |
| OLR1 | chr12:10310898–10324790 | 2.49 | 10.19 | 2.03 |
| IER2 | chr19:13261281–13265718 | 68.06 | 16.68 | -2.03 |
| CPNE7 | chr16:89642175–89663654 | 1.61 | 6.27 | 1.96 |
| CERS4 | chr19:8274216–8327304 | 10.96 | 2.86 | -1.94 |
| CECR1 | chr22:17660191–17690779 | 13.18 | 3.44 | -1.94 |
| CES1 | chr16:55836763–55867075 | 59.97 | 15.70 | -1.93 |
| ISG15 | chr1:948846–949919 | 28.51 | 108.61 | 1.93 |
| SPON1 | chr11:13984183–14289679 | 8.25 | 2.17 | -1.93 |
| PSG5 | chr19:43671894–43690688 | 50.63 | 191.94 | 1.92 |
| FNDC1 | chr6:159590428–159693140 | 4.85 | 1.29 | -1.91 |
| FMO2 | chr1:171154387–171181822 | 14.66 | 3.93 | -1.90 |
| SERPINA3 | chr14:95078713–95090390 | 29.20 | 7.89 | -1.89 |
| PEAR1 | chr1:156863522–156886226 | 2.69 | 9.73 | 1.86 |
| RASL12 | chr15:65337707–65360388 | 24.77 | 6.86 | -1.85 |
| ADAMTS5 | chr21:28290230–28339439 | 5.87 | 20.98 | 1.84 |
| ABCG1 | chr21:43619798–43717354 | 6.48 | 1.83 | -1.82 |
| GDF10 | chr10:48425787–48439138 | 102.61 | 29.10 | -1.82 |
| SGCG | chr13:23755059–23899304 | 1.82 | 6.42 | 1.82 |
| AEBP1 | chr7:44143959–44154159 | 144.69 | 41.17 | -1.81 |
| CCKAR | chr4:26483017–26492042 | 31.20 | 9.09 | -1.78 |
| SHC2 | chr19:416582–460996 | 10.66 | 3.11 | -1.78 |
| HSD17B6 | chr12:57157107–57181574 | 7.60 | 25.93 | 1.77 |
| ALPK2 | chr18:56148481–56296189 | 2.15 | 7.31 | 1.76 |
| PSG1 | chr19:43370612–43383871 | 4.13 | 13.95 | 1.76 |
| GPRC5A | chr12:13043955–13066600 | 6.30 | 21.17 | 1.75 |
| LOC645638 | chr17:58160926–58165828 | 11.94 | 39.70 | 1.73 |
| PTGDS | chr9:139871955–139876194 | 433.66 | 134.15 | -1.69 |
| MYOC | chr1:171604556–171621773 | 13.18 | 4.13 | -1.67 |
| MFAP5 | chr12:8798539–8815433 | 26.25 | 82.96 | 1.66 |
| TBX4 | chr17:59533806–59561664 | 18.10 | 5.73 | -1.66 |
| CHI3L2 | chr1:111770280–111786062 | 46.33 | 14.69 | -1.66 |
| BAMBI | chr10:28966423–28971868 | 5.68 | 17.73 | 1.64 |
| GNG2 | chr14:52327021–52436518 | 5.04 | 1.63 | -1.63 |
| MARCH4 | chr2:217122584–217236750 | 3.17 | 9.32 | 1.56 |
| DMKN | chr19:35988118–36004560 | 39.40 | 13.56 | -1.54 |
| CPA4 | chr7:129932973–129964020 | 3.08 | 8.90 | 1.53 |
| KRT7 | chr12:52626953–52642709 | 13.56 | 39.15 | 1.53 |
| COL14A1 | chr8:121137351–121384273 | 35.38 | 12.27 | -1.53 |
| PLCB4 | chr20:9049700–9461462 | 3.51 | 10.06 | 1.52 |
| SLC2A1 | chr1:43391045–43449029 | 33.40 | 95.72 | 1.52 |
| STEAP3 | chr2:119981383–120023227 | 4.57 | 12.99 | 1.51 |
| GLT25D2 | chr1:183904965–184006863 | 2.27 | 6.43 | 1.50 |
| TFPI2 | chr7:93515744–93520065 | 4.81 | 13.47 | 1.49 |
| PCSK2 | chr20:17206751–17465222 | 7.50 | 2.68 | -1.49 |
| DKK1 | chr10:54074040–54077417 | 17.41 | 47.95 | 1.46 |
| ITGA6 | chr2:173292313–173371181 | 1.81 | 4.98 | 1.46 |
| CLEC3B | chr3:45067758–45077563 | 47.23 | 129.11 | 1.45 |
| FGFR4 | chr5:176513920–176525126 | 6.56 | 2.43 | -1.43 |
| CSRNP1 | chr3:39183341–39195102 | 5.77 | 2.15 | -1.42 |
| SLC7A5 | chr16:87863628–87903100 | 14.64 | 39.01 | 1.41 |
| GPC3 | chrX:132669775–133119673 | 29.19 | 11.03 | -1.40 |
| WISP2 | chr20:43343884–43356452 | 46.81 | 17.71 | -1.40 |
| RGMA | chr15:93586635–93632443 | 11.83 | 4.53 | -1.38 |
| TUFT1 | chr1:151512780–151556059 | 4.50 | 11.74 | 1.38 |
| LOC728392 | chr17:5402746–5404319 | 29.62 | 76.86 | 1.38 |
| F3 | chr1:94994731–95007413 | 18.63 | 48.32 | 1.37 |
| SLC7A11 | chr4:138948576–139163503 | 5.71 | 14.80 | 1.37 |
| SERPINE1 | chr7:100770378–100782547 | 118.50 | 306.35 | 1.37 |
| PDPN | chr1:13910251–13944452 | 9.84 | 3.82 | -1.37 |
| SULF2 | chr20:46286149–46415360 | 33.96 | 13.21 | -1.36 |
| IL32 | chr16:3115312–3119668 | 25.90 | 66.18 | 1.35 |
| DCHS1 | chr11:6642557–6677074 | 6.65 | 2.62 | -1.34 |
| CHRM2 | chr7:136553398–136849088 | 15.63 | 39.61 | 1.34 |
| TLE2 | chr19:2997635–3047633 | 6.74 | 2.67 | -1.34 |
| BST2 | chr19:17513754–17516384 | 8.51 | 21.35 | 1.33 |
| COLEC12 | chr18:319354–500729 | 68.62 | 27.44 | -1.32 |
| RSPO1 | chr1:38076950–38100595 | 7.77 | 3.11 | -1.32 |
| ARHGAP28 | chr18:6834431–6915712 | 5.49 | 2.21 | -1.32 |
| PTPRD | chr9:8314245–10612723 | 4.92 | 1.99 | -1.31 |
| SNHG5 | chr6:86386724–86388451 | 488.49 | 198.98 | -1.30 |